Actually, I meant to give a more meaningful answer.
First of all, don't do just Q&A; have a presentation ready, and give it. First, it lets you orient the discussion and set an agenda for the panel. Second, it gives people time to figure out their questions; I've seen a lot of 'large panels' where a few people just say up in front of a near-empty room, opened the room to questions, and got nothing but silence. I think both times this happened, the 2-hour panels ended in 20 minutes.
Also, be ready to have filler, in case there's a lull in questions. Have controversial statements ready. And jokes. And other cool things.
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First of all, don't do just Q&A; have a presentation ready, and give it. First, it lets you orient the discussion and set an agenda for the panel. Second, it gives people time to figure out their questions; I've seen a lot of 'large panels' where a few people just say up in front of a near-empty room, opened the room to questions, and got nothing but silence. I think both times this happened, the 2-hour panels ended in 20 minutes.
Also, be ready to have filler, in case there's a lull in questions. Have controversial statements ready. And jokes. And other cool things.